Living with the symptoms of primary biliary cholangitisa (PBC) isn’t easy—but there is help available.

Symptoms of PBC can be hard to manage, but it can be helpful to gather information about what to expect and possible treatments to discuss with your healthcare team.

Common symptoms of PBC include, but are not limited to:


Itching, clinically known as pruritus


Fatigue (tiredness)


Dry eyes and mouth


Trouble remembering and concentrating

How much itching or fatigue you feel is not related to how far the disease has progressed or how well your treatment is working.

  • In fact, symptoms may even get better as the liver gets worse
  • Experiencing itching and fatigue does not mean that your medicine is not working

a Formerly known as primary biliary cirrhosis.

Track your symptoms and let your healthcare team know if you need help managing them.

Tracking your symptoms can be helpful because you can show your healthcare team how often and how badly your symptoms impact your life. You can also figure out what works best for treating your symptoms.

  • There are many treatments for pruritus, so speak with your healthcare provider to see if any are right for you
  • Don’t stop taking medicine your doctor has prescribed for your disease—even if the medicine does not make your symptoms better, it may be helping to slow the destruction of your bile ducts

It can be helpful for your healthcare team to see when and how severe your symptoms are between visits.

Use the PBC Living app to help you keep track of your symptoms.

Download PBC Living App

Pruritus (itching) can be a challenging symptom, but treatments can help.

Although there are many possible treatments for pruritus, nearly half of people who experience the symptom may not seek help from a healthcare provider.

  • Itching can happen anywhere on the body
  • Itchy palms and feet may be brushed off as seasonal
  • For some people, itching may become worse at night

Managing itching caused by PBC

In this video, Dr Jennifer Pate, Chief of Psychiatry at Baylor St. Luke’s Medical Center, provides some everyday tips for managing pruritus.

Use this summary of treatment options and discuss them with your healthcare team to see if any of the options listed might help you.

Download fact sheet

Severe fatigue (tiredness) is another common symptom of PBC.

Fatigue related to PBC can affect different people in different ways.

  • It is important to speak with your healthcare team about all of your symptoms so that they can help you get relief
  • In PBC, fatigue may sometimes start after a surgery
  • Treatment and certain techniques are available that may help you cope with the fatigue you may feel

Fighting fatigue caused by PBC

In this video, Dr Jennifer Pate explains how fatigue affects some people living with PBC and provides some tips to help manage it.

Use this fact sheet to discuss with your healthcare team ways to address fatigue that might work for you.

Download fact sheet

The symptoms of PBC can be difficult to manage and may cause stress.

PBC may increase the risk of depression, especially if your symptoms are not diagnosed and treated. It is important to speak with your healthcare team about how your symptoms affect you so they can help you manage those symptoms. Some people find it helpful to keep a journal to show their healthcare team how symptoms are worse or better at certain times of the day or during certain seasons.