Who is at risk for developing primary biliary cholangitisa (PBC)?
Although anyone can be diagnosed with PBC, most people who have the disease are middle-aged women. Many of these women also have at least 1 other autoimmune disease.
PBC may also run in families, so you might be at greater risk if you have a parent, sibling, or child who has been diagnosed with PBC.
a Formerly known as primary biliary cirrhosis.
“When the doctor mentioned [PBC]...I thought, it’s genetic—that I got it from my grandma.”
— Wendy, England
PBC by the numbers
More than 30% of patients with PBC also have another autoimmune disease
About 90% of people who have PBC are women
PBC can appear in people younger than 25 years of age, but most people are diagnosed between 40 and 60 years of age
Although PBC is considered a rare disease, it is the most common chronic cholestatic liver disease in adult women.
What are some factors that can affect PBC progression?
How well someone responds to treatment can affect how fast they progress.
- There is evidence that starting treatment early can help slow the progression of the disease.
- Your healthcare team can see how well your liver is responding to treatment by measuring and tracking your alkaline phosphatase (ALP) levels.
Additionally, women who were diagnosed before the age of 30 and all men (regardless of age) are at highest risk of not responding well to treatment.
You can take action.
Having risk factors for PBC does not mean you will get the disease. Learn more about how people get an official diagnosis of PBC.